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Free Writing Prospectus. Filed Pursuant to Rule Registration Statement No. Dated October 6, Morgan strategy that seeks to provide exposure to a range of asset classes and geographic regions based on the modern portfolio theory approach to asset allocation. The index utilizes the rapidly growing investment options available with ETFs. The levels of the Index 60 reflect the performance of the Basket constituents above the cash index and incorporate the daily deduction of a fee of 0.

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In rice Oryza sativa L. Some indica cultivars show extremely late flowering under long-day conditions, but little is known about the gene s involved. Here, we demonstrate that functional defects in the florigen gene RFT1 are the main cause of late flowering in an indica cultivar, Nona Bokra. Mapping and complementation studies revealed that sequence polymorphisms in the RFT1 regulatory and coding regions are likely to cause late flowering under long-day conditions.

We detected polymorphisms in the promoter region that lead to reduced expression levels of RFT1. Sequencing of the RFT1 region in rice accessions from a global collection showed that the EK mutation is found only in indica , and indicated a strong association between the RFT1 haplotype and extremely late flowering in a functional Hd1 background.

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Correspondence Address : Dr. Pulsatile gonadotropin-releasing hormone GnRH may induce spermatogenesis in most patients with congenital hypogonadotropic hypogonadism CHH by stimulating gonadotropin production, while the predictors for a pituitary response to pulsatile GnRH therapy were rarely investigated. Therefore, the aim of our study is to investigate predictors of the pituitary response to pulsatile GnRH therapy.

This retrospective cohort study included 82 CHH patients who received subcutaneous pulsatile GnRH therapy for at least 1 month. Gonadotropin and testosterone levels, testicular size, and sperm count were compared between the two subgroups before and after GnRH therapy. Among all patients, LH increased from 0. It is concluded that higher levels of triptorelin-stimulated FSH 60min and basal total serum testosterone are favorable predictors of pituitary LH response to GnRH therapy.

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In the current aging society, the number of patients suffering from degenerative brain diseases is continuously increasing. However, many of these brain disorders are intractable and difficult to treat. Non-invasive brain stimulation is an attractive alternative method to a pharmaceutical approach that attempts to treat brain disorders through physical stimulation.

Among the various direct brain stimulation techniques, such as electrical, magnetic, and optical, ultrasound has been proposed as a new modality for neuromodulation due to its distinct advantages such as high spatial resolution and in-depth targeting. As ultrasound modality is still in the early stages of development, further investigations on various aspects such as neuromodulation mechanism, therapeutic effects, and safety are still required. Although ultrasound technology is a mature biomedical tool developed from ultrasound imaging, many new technological advancements such as miniaturized devices based on microelectromechanical systems technology have been recently introduced for the specific purpose of neuromodulation.

In this review, we introduce these new neurotools which are essential to uncovering the fundamental mechanisms of ultrasound brain stimulation and ultimately to developing an effective therapeutic means for brain disorders. While the number of people suffering from brain disorders continues to increase in the modern aging society, it is still a challenge to develop effective treatments for many of these diseases.

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Morgan” has filed a registration statement including a prospectus with the Securities and Exchange Commission the “SEC” for any offerings to which these materials relate. Before you invest in any offering of securities by J. Morgan, you should read the prospectus in that registration statement, the prospectus supplement, as well as the particular product supplement, the relevant term sheet or pricing supplement, and any other documents that J.

Morgan will file with the SEC relating to such offering for more complete information about J. Morgan and the offering of any securities. Alternatively, J. Morgan, any agent, or any dealer participating in the particular offering will arrange to send you the prospectus and the prospectus supplement, as well as any product supplement and term sheet or pricing supplement, if you so request by calling toll-free

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Heading date, a crucial factor determining regional and seasonal adaptation in rice Oryza sativa L. Although considerable progress has been made in our understanding of the molecular regulation of heading date in rice during last two decades, the previously isolated genes and identified quantitative trait loci QTLs cannot fully explain the natural variation for heading date in diverse rice accessions. To genetically dissect naturally occurring variation in rice heading date, we collected QTLs in advanced-backcross populations derived from multiple crosses of the japonica rice accession Koshihikari as a common parental line with 11 diverse rice accessions 5 indica , 3 aus , and 3 japonica that originate from various regions of Asia.

QTL analyses of over 14, backcrossed individuals revealed QTLs distributed widely across the rice genome. The other QTLs were detected in different chromosomal regions than heading date genes. Our results indicate that advanced-backcross progeny allowed us to detect and confirm QTLs with relatively small additive effects, and the natural variation in rice heading date could result from combinations of large- and small-effect QTLs.

We also found differences in the genetic architecture of heading date flowering time among maize, Arabidopsis, and rice. The online version of this article doi Many plant species are able to flower in the seasons best suited to their reproduction. This ability depends mainly on the accurate measurement of seasonal changes in day length and temperature [ 1 , 2 ].

Rice is a short-day plant, i. During last two decades, considerable progress has been made in our understanding of the molecular regulation of heading date in rice [ 4 – 9 ].

Genetic architecture of variation in heading date among Asian rice accessions

Lene Buhl-Mortensen, Kari E. Bottom-trawl fisheries are expanding into deeper habitats and higher latitudes, but our understanding of their effects in these areas is limited. The ecological importance of habitat-forming megabenthos and their vulnerability to trawling is acknowledged, but studies on effects are few. Our objective was to investigate chronic effects of otter trawl fishery on substratum and megabenthos on the shelf 50— m and slope — m in the southern Barents Sea.

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